There was something I noticed while I was reading Deadpool #16. When he and Domino are hashing it out on that rooftop, and he has a gun pointed at her, he extends the pinky finger on the hand holding the gun.
Because I didn't have anything better to do (and it took less than 10 minutes) I flipped back through all the other Medina-drawn Deadpool issues from this year to see if that's typical, and it's not. He extends it during one of his Die Hard hallucinations in #7, but other than that, nothing. Normally Medina draws the pinky finger not bent as much as the others, so it's not tight against the grip like the rest of his hand, but the "teacup" hold, as I've decided to dub it, is rare. I thought maybe Medina was using it to help direct the flow of the panels, draw the audiences' eyes from Wade over to Domino, and it would work that way in #16 (though the gun would have been accomplishing the same thing). However, when he uses it in #7, Wade's aiming the gun into the air, having finished killing the Hans Gruber/Karl/Tiger Shark hallucination, and the panel's in the middle of the page, so it would be directing the reader's eyes back to the previous panels. Of course, that panel has a stretch limo that draws the eye across it, so the finger would be inconsequential in comparison, when it comes to guiding the audience.
So I don't know what it means. Maybe Medina just likes to shake things up a bit, or maybe it's supposed to indicate that Deadpool's relaxed. In the hallucination he'd already killed the bad guy, so crisis averted, and when talking to Domino, he wasn't really planning on killing her. At least, not yet.